Dear Y. N.…
The key factor here is that your agent gave the writing itself a thumbs up. She’s not afraid this project will hurt your reputation; it’s clearly a numbers thing. Knowing that, I say do your round of smaller press submissions. A small press isn’t as dependent on huge yearly sales as a Big House (although they’d sure love to score huge sales) and so may be that risk-taking house you’re looking for. Either you’ll get a book deal (yay!) or you’ll get peace of mind that you’ve given this story a shot at the bound cover.