If that’s all your story is—“a vampire book”— then yes, they’ll roll their eyes. The market has plenty of those. That hook is no longer enough to make a sale. Your paranormal story must be more than its monsters. One thing I hear editors asking for now is cross-genre paranormal to offer readers who love vampires something fresh. “Vampire” has been done; “Vampire astronauts who take over the first human colony on Mars” has not. Don’t simply get gimmicky, though. A genre blend must be a natural one, with a solid story at its core. Gimmicks may get attention, but solid storytelling earns the sale.